Custom Peptides
Cayman Chemical TetrahydrourIdIn 10mg
A cytidine deaminase inhibitor (Kis = 54 and 240 nM for the human and E. coli enzymes, respectively); inhibits the metabolism of decitabine and enhances decitabine-induced inhibition of tumor growth in a B16 murine melanoma model
Cayman Chemical DC4 CroslInker 10mg
A MS-cleavable crosslinking reagent (18Å in length) that contains two intrinsic positive charges, which allow cross-linked peptides to fragment into their component peptides by collision-induced dissociation or in-source decay
Cayman Chemical Ro 25-6981maleate 10mg
A potent, selective activity-dependent blocker of NMDA receptors containing the NR2B subunit (IC50 = 9 nM); displays neuroprotectant effects in cortical neurons in vitro (IC50 = 0.04-0.4 μM)
Cayman Chemical ProstaglndIn F1a 10mg
PGF1α is the putative metabolite of DGLA via the COX pathway. Both PGF1α and PGF2α have been shown to act as priming pheromones for male Atlantic salmon with a threshold concentration of 10−11 M.{3467} PGF1α binds to the ovine corpus luteum FP receptor at only 8% of the relative potency of PGF2α.{2058} It is only half as active as PGF2α in inducing human respiratory smooth muscle contractions in vitro.{2218}
Cayman Chemical LIpoxygenIn 10mg
A 5-LO inhibitor (IC50 = 5 µM for A23187-stimulated 5-LO product synthesis in isolated human granulocytes); inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, BMP-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 µM, respectively, in luciferase reporter assays); increases TnnT levels in BMP4- and CHIR99021-stimulated human iPSCs
Cayman Chemical Salva plba . B. spduln 10mg
A flavonoid with diverse biological activities; inhibits PAF-, arachidonic acid-, and ADP-induced platelet aggregation (IC50s = 20, 4, and 13 μM, respectively); inhibits RANKL-induced osteoclastic differentiation of RAW 264.7 cells and BMMs; inhibits LPS-induced bone resorption in mice at 25 μg/kg; inhibits tumor growth in a Caki-2 mouse xenograft model; reduces sevoflurane-induced cognitive deficits in aged rats at 40 mg/kg; decreases infarct size and brain edema in a rat model of focal cerebral ischemia and reperfusion injury
Cayman Chemical DegarelIxacetate 10mg
A synthetic GNRHR antagonist (IC50 = 3 nM in HEK293 cells expressing the human receptor); inhibits the growth of WPMY-1, WPE1-NA22, BPH-1, and LNCaP prostate cell lines via caspase activation and induction of apoptosis (10 μM); decreases plasma testosterone levels in rats to castrate levels for the first 49 days post treatment (2 mg/kg); decreases tumor volume of Dunning R3327H prostate tumor flank implants in rats (1 mg/kg per month)
Cayman Chemical XamoterolhemIfumarate 10mg
A β1-adrenergic receptor partial agonist (EC50 = 80 nM for the generation of cAMP in neonatal rat cardiomyocyte cultures); increases spontaneous contraction of isolated rat right atria (EC50 = 4.67 nM); increases heart rate in beagle dogs (ED50 = 3.2 UG/kg) and a rat model of spontaneous heart failure (ED50 = 6 UG/kg)
Cayman Chemical NudIfloramIde 10mg
An active metabolite of nicotinamide; an inhibitor of PARP (IC50 = 8 µM); plasma levels are increased in patients with chronic renal failure
Cayman Chemical 2-IodomelatonIn 10mg
A potent MT1 receptor agonist (Ki = 28 pM); 5-fold selective for MT1 over MT2; inhibits forskolin-stimulated cAMP production in CHO cells expressing human MT1 (EC50 = 11 pM); has been used to characterize the role of MT1 in melatonin-mediated signaling
Cayman Chemical BromosporIn 10mg
A non-selective bromodomain inhibitor that at 1 µM has been shown to accelerate FRAP recovery of BRD4 and CREBBP bromodomains in HeLa cells
Cayman Chemical UR-144 Degradnt 10mg
A common impurity observed during GC-MS analysis of samples containing UR-144, featuring an opened ring presumed to be produced during heating; gives rise to a prominent fragment ion that is 15 amu greater than the base peak of UR-144
Cayman Chemical -ClopIdogrelhydrochlorId 10mg
A racemic mixture of (R)-(–)-clopidogrel and (S)-(+)-clopidogrel
Cayman Chemical WIthnolIde B 10mg
A withanolide; identified as an nNOS inhibitor in an in silico docking study (Ki = 5.15 nM) that also inhibits iNOS and eNOS (Kis = 15.48 and 66.59 nM, respectively); identified as a ligand for the PARP1 catalytic domain in an in silico docking study with an estimated Ki value of 7.54 nM
Cayman Chemical EpIrubIcInhydrochlorIde 10mg
A stereoisomer of the antitumor anthracycline doxorubicin that undergoes β-glucuronidation, which partially detoxifies the dose-limiting side effects that are present with doxorubicin; equally cytotoxic to HeLa cells compared to doxorubicin (ID50s = 9 μM)